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Taylor group: Translational Genomics

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Translation of genetics research into clinical practice

Research overview

Oxford Biomedical Research Centre – Genomic Medicine Theme

Jenny Taylor

Professor Jenny Taylor is Co-Theme Leader of the Genomic Medicine Theme of the Oxford Biomedical Research Centre (BRC), one of several such centres in the UK funded by the National Institute of Health Research with the overarching aim of translating advances in biomedical research into NHS practice.

The aims of the Genomic Medicine Theme are to:

  • apply next-generation sequencing technologies (NGS) to the discovery of novel disease genes
  • evaluate and develop these technologies for rapid translation into the clinic, resulting in new NHS-based genetics services
  • provide genetics and genomics infrastructure (platforms and expertise) to support other translational research projects

Our research is truly multi-disciplinary, integrating researchers and clinicians (particularly those based at the Centre) from a range of medical specialities, with clinical scientists from the diagnostic laboratories, and others, including specialists in health economics, informatics, and ethics.

The activities of the Genomic Medicine Theme are divided into three sub-themes, each with a specific programme of collaborative projects.  Members of the Taylor group are involved across all three sub-themes, either running projects of their own or as collaborators in wider programmes.

Clinical applications of sequencing

Mechanisms to biomarkers

Technology translation

Our team

Selected publications

Latest publications

Biallelic variants in the noncoding RNA gene RNU4-2 cause a recessive neurodevelopmental syndrome with distinct white matter changes.

Journal article

Rius R. et al, (2026), Nat Genet

Saturation editing of RNU4-2 reveals distinct dominant and recessive disorders.

Journal article

De Jonghe J. et al, (2026), Nature

Paediatric case of invasive group A streptococcal necrotising myositis: diagnostic challenges and lessons learned

Journal article

Yusuf S. et al, (2026), The Lancet Infectious Diseases, 26, e259 - e267

CMS subtypes correlate with complete response in trial of neoadjuvant Galunisertib plus chemoradiation in rectal cancer

Journal article

Rajamanickam V. et al, (2026), Translational Oncology, 66, 102690 - 102690

Ethics Review of AI research: An approach to reviewing and revising existing governance structures

Journal article

Kerasidou A. et al, (2026), Research Ethics, 22, 357 - 370

Toward Integration of Molecular Measures and Artificial Intelligence-Based Assessments With Clinical End Points in Inflammatory Bowel Disease

Journal article

Reinisch W. et al, (2026), Gastroenterology, 170, 686 - 703

Short RFamide, CFamide and FCamide peptides as novel positive modulators of ASIC3 with similar potentiating effects but different reversibility.

Journal article

Toft M. et al, (2026), Neuropharmacology, 287

Cattle antibodies identify a cross-serotype broadly neutralising foot-and-mouth disease virus epitope.

Journal article

Bonnet-Di Placido M. et al, (2026), NPJ vaccines

Women with chronic pelvic pain can be stratified using multimodal assessment.

Journal article

Demetriou L. et al, (2026), Pain, 167, 786 - 802

Therapeutic manipulation and spatial quantification of the tumor microenvironment in colorectal cancer.

Journal article

Mulholland-Illingworth EJ. et al, (2026), iScience, 29

Related research themes

Translational genetics